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Deleting nebulin's C-terminus reveals its importance to sarcomeric structure and function and is sufficient to invoke nemaline myopathy

Nebulin is a large skeletal muscle protein wound around the thin filaments, with its C-terminus embedded within the Z-disk and its N-terminus extending out toward the thin filament pointed end. While nebulin's C-terminus has been implicated in both sarcomeric structure and function as well as t...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Li, Frank, Barton, Elisabeth R, Granzier, Henk
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494792/
https://ncbi.nlm.nih.gov/pubmed/30689900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz016
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