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Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy

Nemaline myopathy (NEM) is a congenital neuromuscular disorder primarily caused by nebulin gene (NEB) mutations. NEM is characterized by muscle weakness for which currently no treatments exist. In NEM patients a predominance of type I fibers has been found. Thus, therapeutic options targeting type I...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lindqvist, Johan, Lee, Eun-Jeong, Karimi, Esmat, Kolb, Justin, Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853306/
https://ncbi.nlm.nih.gov/pubmed/31721788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224467
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