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The γ‐Secretase Blocker DAPT Reduces the Permeability of the Blood–Brain Barrier by Decreasing the Ubiquitination and Degradation of Occludin During Permanent Brain Ischemia
BACKGROUND: Tight junction protein degradation is a principal characteristic of the blood–brain barrier (BBB) damage that occurs during brain ischemia. AIMS: We investigated the mechanisms of occludin degradation that underlie permanent middle cerebral artery occlusion (pMCAO) in rats. METHODS AND R...
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| Publicat a: | CNS Neurosci Ther |
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| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6493664/ https://ncbi.nlm.nih.gov/pubmed/23171401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12032 |
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