The γ‐Secretase Blocker DAPT Reduces the Permeability of the Blood–Brain Barrier by Decreasing the Ubiquitination and Degradation of Occludin During Permanent Brain Ischemia

BACKGROUND: Tight junction protein degradation is a principal characteristic of the blood–brain barrier (BBB) damage that occurs during brain ischemia. AIMS: We investigated the mechanisms of occludin degradation that underlie permanent middle cerebral artery occlusion (pMCAO) in rats. METHODS AND R...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Zhang, Gen‐Sheng, Tian, Yun, Huang, Ji‐Yun, Tao, Rong‐Rong, Liao, Mei‐Hua, Lu, Ying‐Mei, Ye, Wei‐Feng, Wang, Rui, Fukunaga, Kohji, Lou, Yi‐Jia, Han, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493664/
https://ncbi.nlm.nih.gov/pubmed/23171401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12032
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