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Small molecule ion channels increase host defenses in cystic fibrosis airway epithelia
Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO(3)(−) and Cl(−) secretion, reduce airway surface liquid (ASL) pH, and impair respiratory host defenses in people with cystic fibrosis (CF) (1–3). Here we report that apical addition...
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| Pubblicato in: | Nature |
|---|---|
| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6492938/ https://ncbi.nlm.nih.gov/pubmed/30867598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1018-5 |
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