Small molecule ion channels increase host defenses in cystic fibrosis airway epithelia

Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO(3)(−) and Cl(−) secretion, reduce airway surface liquid (ASL) pH, and impair respiratory host defenses in people with cystic fibrosis (CF) (1–3). Here we report that apical addition...

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Publicado en:Nature
Main Authors: Muraglia, Katrina A., Chorghade, Rajeev S., Kim, Bo Ram, Tang, Xiao Xiao, Shah, Viral S., Grillo, Anthony S., Daniels, Page N., Cioffi, Alexander G., Karp, Philip H., Zhu, Lingyang, Welsh, Michael J., Burke, Martin D.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492938/
https://ncbi.nlm.nih.gov/pubmed/30867598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1018-5
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