Human cystic fibrosis airway epithelia have reduced Cl(−) conductance but not increased Na(+) conductance

Loss of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function causes cystic fibrosis (CF) lung disease. CFTR is expressed in airway epithelia, but how CF alters electrolyte transport across airway epithelia has remained uncertain. Recent studies of a porcine model showed...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Itani, Omar A., Chen, Jeng-Haur, Karp, Philip H., Ernst, Sarah, Keshavjee, Shaf, Parekh, Kalpaj, Klesney-Tait, Julia, Zabner, Joseph, Welsh, Michael J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121869/
https://ncbi.nlm.nih.gov/pubmed/21646513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106695108
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