Human cystic fibrosis airway epithelia have reduced Cl(−) conductance but not increased Na(+) conductance

Loss of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function causes cystic fibrosis (CF) lung disease. CFTR is expressed in airway epithelia, but how CF alters electrolyte transport across airway epithelia has remained uncertain. Recent studies of a porcine model showed...

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Main Authors: Itani, Omar A., Chen, Jeng-Haur, Karp, Philip H., Ernst, Sarah, Keshavjee, Shaf, Parekh, Kalpaj, Klesney-Tait, Julia, Zabner, Joseph, Welsh, Michael J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2011
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121869/
https://ncbi.nlm.nih.gov/pubmed/21646513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106695108
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