Human cystic fibrosis airway epithelia have reduced Cl(−) conductance but not increased Na(+) conductance

Loss of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function causes cystic fibrosis (CF) lung disease. CFTR is expressed in airway epithelia, but how CF alters electrolyte transport across airway epithelia has remained uncertain. Recent studies of a porcine model showed...

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Bibliografische gegevens
Hoofdauteurs: Itani, Omar A., Chen, Jeng-Haur, Karp, Philip H., Ernst, Sarah, Keshavjee, Shaf, Parekh, Kalpaj, Klesney-Tait, Julia, Zabner, Joseph, Welsh, Michael J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121869/
https://ncbi.nlm.nih.gov/pubmed/21646513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106695108
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