Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia

Defective transepithelial electrolyte transport is thought to initiate cystic fibrosis (CF) lung disease. Yet, how loss of CFTR affects electrolyte transport remains uncertain. CFTR(−/−) pigs spontaneously develop lung disease resembling human CF. At birth, their airways exhibit a bacterial host def...

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Bibliografiske detaljer
Main Authors: Chen, Jeng-Haur, Stoltz, David A., Karp, Philip H., Ernst, Sarah E., Pezzulo, Alejandro A., Moninger, Thomas O., Rector, Michael V., Reznikov, Leah R., Launspach, Janice L., Chaloner, Kathryn, Zabner, Joseph, Welsh, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057187/
https://ncbi.nlm.nih.gov/pubmed/21145458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.029
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