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Hyperglycemia Increases the Production of Amyloid Beta‐Peptide Leading to Decreased Endothelial Tight Junction
AIMS: Amyloid beta‐peptide (Aβ), the main component of senile plaques in the Alzheimer's disease (AD) brains, is generated from sequential cleavage of amyloid precursor protein (APP) by β‐ and γ‐secretase. Hyperglycemia in diabetes may compromise barrier integrity in endothelial cells (ECs). Ho...
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| Publicado no: | CNS Neurosci Ther |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6492831/ https://ncbi.nlm.nih.gov/pubmed/26842741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12503 |
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