Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta‐Amyloid Deposition in Mice via BACE1‐Antisense Activation

AIMS: To clarify the correlation between chronic sleep restriction (CSR) and sporadic Alzheimer disease (AD), we determined in wild‐type mice the impact of CSR, on cognitive performance, beta‐amyloid (Aβ) peptides, and its feed‐forward regulators regarding AD pathogenesis. METHODS: Sixteen nine‐mont...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Zhao, Hong‐Yi, Wu, Hui‐Juan, He, Jia‐Lin, Zhuang, Jian‐Hua, Liu, Zhen‐Yu, Huang, Liu‐Qing, Zhao, Zhong‐Xin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492718/
https://ncbi.nlm.nih.gov/pubmed/28145081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12667
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