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Impact of RTN3 Deficiency on Expression of BACE1 and Amyloid Deposition

Reticulon 3 (RTN3) has previously been shown to interact with BACE1 and negatively regulate BACE1 activity. To what extent RTN3 deficiency affects BACE1 activity is an intriguing question. In this study, we aimed to address this by generating RTN3-null mice. Mice with complete deficiency of RTN3 gro...

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Detalhes bibliográficos
Main Authors: Shi, Qi, Ge, Yingying, Sharoar, Md. Golam, He, Wanxia, Xiang, Rong, Zhang, Zhuohua, Hu, Xiangyou, Yan, Riqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198539/
https://ncbi.nlm.nih.gov/pubmed/25319692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1588-14.2014
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