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RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer’s brains
Reticulon proteins (RTNs), consisting of RTN1 to RTN4, were previously shown to interact with BACE1 by negatively modulating its secretase activity. In RTN3-null mice, RTN1 expression was slightly elevated. To understand the in vivo role of RTN1, we generated RTN1-null mice and compared the effects...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5522448/ https://ncbi.nlm.nih.gov/pubmed/28733667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05504-9 |
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