Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer’s disease

Pathological features in Alzheimer’s brains include mitochondrial dysfunction and dystrophic neurites (DNs) in areas surrounding amyloid plaques. Using a mouse model that overexpresses reticulon 3 (RTN3) and spontaneously develops age-dependent hippocampal DNs, here we report that DNs contain both R...

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Pubblicato in:Mol Psychiatry
Autori principali: Sharoar, Md. Golam, Shi, Qi, Ge, Yingying, He, Wanxia, Hu, Xiangyou, Perry, George, Zhu, Xiongwei, Yan, Riqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887420/
https://ncbi.nlm.nih.gov/pubmed/26619807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.181
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