Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer’s disease

Pathological features in Alzheimer’s brains include mitochondrial dysfunction and dystrophic neurites (DNs) in areas surrounding amyloid plaques. Using a mouse model that overexpresses reticulon 3 (RTN3) and spontaneously develops age-dependent hippocampal DNs, here we report that DNs contain both R...

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Bibliografiske detaljer
Udgivet i:Mol Psychiatry
Main Authors: Sharoar, Md. Golam, Shi, Qi, Ge, Yingying, He, Wanxia, Hu, Xiangyou, Perry, George, Zhu, Xiongwei, Yan, Riqiang
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887420/
https://ncbi.nlm.nih.gov/pubmed/26619807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.181
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