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BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions
BACE1 initiates the generation of the β-amyloid peptide, which likely causes Alzheimer’s disease (AD) when accumulated abnormally. BACE1 inhibitory drugs are currently being developed to treat AD patients. To mimic BACE1 inhibition in adults, we generated BACE1 conditional knockout (BACE1(fl/fl)) mi...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839766/ https://ncbi.nlm.nih.gov/pubmed/29444819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171831 |
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