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Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression
β-Site amyloid precursor protein convertase enzyme 1 (BACE1), a type I transmembrane aspartyl protease required to cleave amyloid precursor protein for releasing a toxic amyloid peptide, also cleaves type I and type III neuregulin-1 (Nrg-1). BACE1 deficiency in mice causes hypomyelination during dev...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633823/ https://ncbi.nlm.nih.gov/pubmed/23335052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-224212 |
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