Androgen alleviates neurotoxicity of β‐amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ

AIMS: Lower androgen level in elderly men is a risk factor of Alzheimer's disease (AD). It has been reported that androgen reduces amyloid peptides (Aβ) production and increases Aβ degradation by neurons. Activated microglia are involved in AD by either clearing Aβ deposits through uptake of Aβ...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Yao, Peng‐Le, Zhuo, Shu, Mei, Hong, Chen, Xiao‐Fang, Li, Na, Zhu, Teng‐Fei, Chen, Shi‐Ting, Wang, Ji‐Ming, Hou, Rui‐Xing, Le, Ying‐Ying
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492702/
https://ncbi.nlm.nih.gov/pubmed/28941188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12757
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