Androgen alleviates neurotoxicity of β‐amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ

AIMS: Lower androgen level in elderly men is a risk factor of Alzheimer's disease (AD). It has been reported that androgen reduces amyloid peptides (Aβ) production and increases Aβ degradation by neurons. Activated microglia are involved in AD by either clearing Aβ deposits through uptake of Aβ...

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Vydáno v:CNS Neurosci Ther
Hlavní autoři: Yao, Peng‐Le, Zhuo, Shu, Mei, Hong, Chen, Xiao‐Fang, Li, Na, Zhu, Teng‐Fei, Chen, Shi‐Ting, Wang, Ji‐Ming, Hou, Rui‐Xing, Le, Ying‐Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492702/
https://ncbi.nlm.nih.gov/pubmed/28941188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12757
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