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Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

Early microglial accumulation in Alzheimer's disease (AD) delays disease progression by promoting clearance of β-amyloid (Aβ) before formation of senile plaques. However, persistent Aβ accumulation despite increasing microglial numbers suggests that the ability of microglia to clear Aβ may decr...

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Bibliografiska uppgifter
Huvudupphovsmän: Hickman, Suzanne E., Allison, Elizabeth K., El Khoury, Joseph
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2008
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597474/
https://ncbi.nlm.nih.gov/pubmed/18701698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0616-08.2008
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