Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

BACKGROUND: β-Amyloid peptide (Aβ) is a major protein in the brain associated with Alzheimer's and Parkinson's diseases. The purpose of this study was to investigate the role of macrophage antigen-1 (MAC1) receptor, an integrin scavenger receptor in microglia, and subsequent signaling even...

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Bibliografski detalji
Glavni autori: Zhang, Dan, Hu, Xiaoming, Qian, Li, Chen, Shih-Heng, Zhou, Hui, Wilson, Belinda, Miller, David S, Hong, Jau-Shyong
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027117/
https://ncbi.nlm.nih.gov/pubmed/21232086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-3
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