Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models

Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of hepatocytes. ABCB4 deficiency, due to genetic variations, is responsible for progressive familial intrahepatic cholestasis type 3 (PFIC3) and oth...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Vauthier, Virginie, Ben Saad, Amel, Elie, Jonathan, Oumata, Nassima, Durand-Schneider, Anne-Marie, Bruneau, Alix, Delaunay, Jean-Louis, Housset, Chantal, Aït-Slimane, Tounsia, Meijer, Laurent, Falguières, Thomas
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491434/
https://ncbi.nlm.nih.gov/pubmed/31040306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43111-y
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