Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis

BACKGROUND: Sepsis, the most severe form of infection, involves endothelial dysfunction which contributes to organ failure. To improve therapeutic prospects, elucidation of molecular mechanisms underlying endothelial vascular failure is of essence. METHODS: Polymicrobial contamination induced sepsis...

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Publicado en:EBioMedicine
Autores principales: Heun, Yvonn, Pircher, Joachim, Czermak, Thomas, Bluem, Philipp, Hupel, Georg, Bohmer, Monica, Kraemer, Bjoern F., Pogoda, Kristin, Pfeifer, Alexander, Woernle, Markus, Ribeiro, Andrea, Hübner, Max, Kreth, Simone, Claus, Ralf A., Weis, Sebastian, Ungelenk, Luisa, Krötz, Florian, Pohl, Ulrich, Mannell, Hanna
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491420/
https://ncbi.nlm.nih.gov/pubmed/30905847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.034
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