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DNA intercalation facilitates efficient DNA-targeted covalent binding of phenanthriplatin
Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly enhanced DNA covalent binding activity compared to its parent complex. To understand the underlying molecular mechanism, we use single molecule studies with optical tweezers to probe the kinetics of DNA-p...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6491043/ https://ncbi.nlm.nih.gov/pubmed/30599508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b10252 |
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