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X-ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels

X-ray crystallography is a powerful tool in structural biology and can offer insight into structured-based understanding of general anesthetic action on various relevant molecular targets, including pentameric ligand-gated ion channels (pLGICs). In this chapter, we outline the procedures for express...

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Detalhes bibliográficos
Publicado no:Methods Enzymol
Main Authors: Chen, Qiang, Xu, Yan, Tang, Pei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6490682/
https://ncbi.nlm.nih.gov/pubmed/29673527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2018.01.017
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