Signal transduction pathways in the pentameric ligand-gated ion channels.

The mechanisms of allosteric action within pentameric ligand-gated ion channels (pLGICs) remain to be determined. Using crystallography, site-directed mutagenesis, and two-electrode voltage clamp measurements, we identified two functionally relevant sites in the extracellular (EC) domain of the bact...

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Autores principales: David Mowrey, Qiang Chen, Yuhe Liang, Jie Liang, Yan Xu, Pei Tang
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3648548?pdf=render
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