Conformational Changes Underlying Desensitization of the Pentameric Ligand-gated Ion Channel ELIC

Structural rearrangements underlying functional transitions of pentameric ligand-gated ion channels (pLGICs) are not fully understood. Using (19)F NMR and ESR spectroscopy, we found that ELIC, a pLGIC from Erwinia chrysanthemi, expanded the extracellular end and contracted the intracellular end of i...

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Publicat a:Structure
Autors principals: Kinde, Monica N., Chen, Qiang, Lawless, Matthew J., Mowrey, David D., Xu, Jiawei, Saxena, Sunil, Xu, Yan, Tang, Pei
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456284/
https://ncbi.nlm.nih.gov/pubmed/25960405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.03.017
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