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Ketamine Inhibition of the Pentameric Ligand-Gated Ion Channel GLIC
Ketamine inhibits pentameric ligand-gated ion channels (pLGICs), including the bacterial pLGIC from Gloeobacter violaceus (GLIC). The crystal structure of GLIC shows R-ketamine bound to an extracellular intersubunit cavity. Here, we performed molecular dynamics simulations of GLIC in the absence and...
Shranjeno v:
| izdano v: | Biophys J |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Biophysical Society
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5550297/ https://ncbi.nlm.nih.gov/pubmed/28793215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.06.041 |
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