Ketamine Inhibition of the Pentameric Ligand-Gated Ion Channel GLIC

Ketamine inhibits pentameric ligand-gated ion channels (pLGICs), including the bacterial pLGIC from Gloeobacter violaceus (GLIC). The crystal structure of GLIC shows R-ketamine bound to an extracellular intersubunit cavity. Here, we performed molecular dynamics simulations of GLIC in the absence and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Ion, Bogdan F., Wells, Marta M., Chen, Qiang, Xu, Yan, Tang, Pei
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2017
Sujets:
Channels and Transporters
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550297/
https://ncbi.nlm.nih.gov/pubmed/28793215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.06.041
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