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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound With Anesthetic Ketamine
Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibiti...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3446250/ https://ncbi.nlm.nih.gov/pubmed/22958642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.009 |
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