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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound With Anesthetic Ketamine

Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibiti...

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Bibliografski detalji
Glavni autori: Pan, Jianjun, Chen, Qiang, Willenbring, Dan, Mowrey, David, Kong, Xiang-Peng, Cohen, Aina, Divito, Christopher B., Xu, Yan, Tang, Pei
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446250/
https://ncbi.nlm.nih.gov/pubmed/22958642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.009
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