Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound With Anesthetic Ketamine

Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibiti...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pan, Jianjun, Chen, Qiang, Willenbring, Dan, Mowrey, David, Kong, Xiang-Peng, Cohen, Aina, Divito, Christopher B., Xu, Yan, Tang, Pei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446250/
https://ncbi.nlm.nih.gov/pubmed/22958642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.009
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