A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas

Schwannomas are common, highly morbid and medically untreatable tumors that can arise in patients with germ line as well as somatic mutations in neurofibromatosis type 2 (NF2). These mutations most commonly result in the loss of function of the NF2-encoded protein, Merlin. Little is known about how...

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Pubblicato in:Hum Mol Genet
Autori principali: Gehlhausen, Jeffrey R, Hawley, Eric, Wahle, Benjamin Mark, He, Yongzheng, Edwards, Donna, Rhodes, Steven D, Lajiness, Jacquelyn D, Staser, Karl, Chen, Shi, Yang, Xianlin, Yuan, Jin, Li, Xiaohong, Jiang, Li, Smith, Abbi, Bessler, Waylan, Sandusky, George, Stemmer-Rachamimov, Anat, Stuhlmiller, Timothy J, Angus, Steven P, Johnson, Gary L, Nalepa, Grzegorz, Yates, Charles W, Wade Clapp, D, Park, Su-Jung
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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General Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489415/
https://ncbi.nlm.nih.gov/pubmed/30335132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy361
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