Chemopreventative celecoxib fails to prevent schwannoma formation or sensorineural hearing loss in genetically engineered murine model of neurofibromatosis type 2

Mutations in the tumor suppressor gene NF2 lead to Neurofibromatosis type 2 (NF2), a tumor predisposition syndrome characterized by the development of schwannomas, including bilateral vestibular schwannomas with complete penetrance. Recent work has implicated the importance of COX-2 in schwannoma gr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wahle, Benjamin M., Hawley, Eric T., He, Yongzheng, Smith, Abbi E., Yuan, Jin, Masters, Andi R., Jones, David R., Gehlhausen, Jeffrey R., Park, Su-Jung, Conway, Simon J., Clapp, D. Wade, Yates, Charles W.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787503/
https://ncbi.nlm.nih.gov/pubmed/29416648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22002
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