Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib

Sorafenib remains the standard care for patients with hepatocellular carcinoma (HCC) even though it has low antitumor efficacy. Protein neddylation is abnormally activated in many types of human cancer. However, whether dysregulation of neddylation is involved in HCC progression and whether targetin...

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Udgivet i:Oncol Rep
Main Authors: Yang, Zelong, Zhang, Jie, Lin, Xiaotong, Wu, Di, Li, Guixi, Zhong, Chunlian, Fang, Lei, Jiang, Peng, Yin, Liangyu, Zhang, Leida, Bie, Ping, Xie, Chuan-Ming
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489087/
https://ncbi.nlm.nih.gov/pubmed/31002342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2019.7098
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