Pronounced antiepileptic activity of the subtype‐selective GABA(A)‐positive allosteric modulator PF‐06372865 in the GAERS absence epilepsy model

AIM: Antiepileptic drugs that modulate GABA have the potential to aggravate or improve the symptoms of absence epilepsy. PF‐06372865 is a positive allosteric modulator (PAM) of α2/3/5 subunit‐containing GABA(A) receptors with minimal activity at α1‐containing receptors, which are believed to mediate...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Duveau, Venceslas, Buhl, Derek L., Evrard, Alexis, Ruggiero, Céline, Mandé‐Niedergang, Betty, Roucard, Corinne, Gurrell, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488884/
https://ncbi.nlm.nih.gov/pubmed/30101518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13046
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