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UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells

Scaling up blood cell production from hPSCs is critical to advancing hPSC technologies for blood transfusion, immunotherapy, and transplantation. Here we explored the potential of the HSC agonist pyrimido-indole derivative UM171, to expand hematopoietic progenitors (HPs) derived from hPSCs in chemic...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Mesquitta, Walatta-Tseyon, Wandsnider, Matthew, Kang, HyunJun, Thomson, James, Moskvin, Oleg, Suknuntha, Kran, Slukvin, Igor I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488662/
https://ncbi.nlm.nih.gov/pubmed/31036928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43054-4
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