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GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition

The transcriptional factor GATA2 is required for blood and hematopoietic stem cell formation during the hemogenic endothelium (HE) stage of development in the embryo. However, it is unclear if GATA2 controls HE lineage specification or if it solely regulates endothelial-to-hematopoietic transition (...

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Détails bibliographiques
Publié dans:Stem Cell Reports
Auteurs principaux: Kang, HyunJun, Mesquitta, Walatta-Tseyon, Jung, Ho Sun, Moskvin, Oleg V., Thomson, James A., Slukvin, Igor I.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066910/
https://ncbi.nlm.nih.gov/pubmed/29861167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.05.002
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