USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia

Constitutive activation of tyrosine kinase Bcr-Abl is the leading cause of the development and progression of chronic myeloid leukemia (CML). Currently, the application of tyrosine kinase inhibitors (TKIs) targeting the Bcr-Abl is the primary therapy for CML patients. However, acquired resistance to...

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Dettagli Bibliografici
Pubblicato in:Cell Discov
Autori principali: Liao, Yuning, Liu, Ningning, Xia, Xiaohong, Guo, Zhiqiang, Li, Yanling, Jiang, Lili, Zhou, Ruiqing, Tang, Daolin, Huang, Hongbiao, Liu, Jinbao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488640/
https://ncbi.nlm.nih.gov/pubmed/31044085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-019-0092-z
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