Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

BACKGROUND: Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML). Bcr-Abl-T315I mutation is the predominant mechanism of the acquired resistance to IM. Therefore, it is urge...

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發表在:J Hematol Oncol
Main Authors: Lan, Xiaoying, Zhao, Chong, Chen, Xin, Zhang, Peiquan, Zang, Dan, Wu, Jinjie, Chen, Jinghong, Long, Huidan, Yang, Li, Huang, Hongbiao, Carter, Bing Z., Wang, Xuejun, Shi, Xianping, Liu, Jinbao
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
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Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123219/
https://ncbi.nlm.nih.gov/pubmed/27884201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0359-x
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