Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

PURPOSE: Chronic myelogenous leukemia (CML) is characterized by the constitutive activation of Bcr-Abl tyrosine kinase. Bcr-Abl-T315I is the predominant mutation that causes resistance to imatinib, cytotoxic drugs, and the second-generation tyrosine kinase inhibitors. The emergence of imatinib resis...

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Hlavní autoři: Shi, Xianping, Chen, Xin, Li, Xiaofen, Lan, Xiaoying, Zhao, Chong, Liu, Shouting, Huang, Hongbiao, Liu, Ningning, Liao, Siyan, Song, Wenbin, Zhou, Ping, Wang, Shunqing, Xu, Li, Wang, Xuejun, Dou, Q. Ping, Liu, Jinbao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938960/
https://ncbi.nlm.nih.gov/pubmed/24334603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1063
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