Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Resistance to Imatinib mesylate (IM) is an emerging problem for patients with chronic myelogenous leukemia (CML). T315I mutation in the Bcr-Abl is the predominant mechanism of the acquired resistance to IM and second generation tyrosine kinase inhibitors (TKI). Therefore it is urgent to search for n...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chen, Xin, Shi, Xianping, Zhao, Chong, Li, Xiaofen, Lan, Xiaoying, Liu, Shouting, Huang, Hongbiao, Liu, Ningning, Liao, Siyan, Zang, Dan, Song, Wenbin, Liu, Quentin, Carter, Bing Z., Dou, Q. Ping, Wang, Xuejun, Liu, Jinbao
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253423/
https://ncbi.nlm.nih.gov/pubmed/25193854
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