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Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis
Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes (DUBs) and find that the ubiquitin-specific pro...
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8105359/ https://ncbi.nlm.nih.gov/pubmed/33963175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03732-6 |
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