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It takes a team: a gain-of-function story of p53-R249S
Gain-of-function (GOF), the most malicious oncogenic activity of a cancer-promoting protein, is well illustrated to three hotspot p53 mutations at R248, R175, and R273 with distinct molecular mechanisms. Yet, less is known about another hotspot p53 mutant, R249S (p53-R249S). p53-R249S is the sole ho...
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| Publicado no: | J Mol Cell Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6487778/ https://ncbi.nlm.nih.gov/pubmed/30608603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjy086 |
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