Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome

Disruption of cellular iron homeostasis can contribute to neurodegeneration. In mammals, two iron-regulatory proteins (IRPs) shape the expression of the iron metabolism proteome. Targeted deletion of Ireb2 in a mouse model causes profoundly disordered iron metabolism, leading to functional iron defi...

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Vydáno v:Brain
Hlavní autoři: Costain, Gregory, Ghosh, Manik C, Maio, Nunziata, Carnevale, Amanda, Si, Yue C, Rouault, Tracey A, Yoon, Grace
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487337/
https://ncbi.nlm.nih.gov/pubmed/30915432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz072
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