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A minimal physiologically-based pharmacokinetic model with a nested endosome compartment for novel engineered antibodies
We proposed here a minimal physiologically-based pharmacokinetic (mPBPK) m6odel for a group of novel engineered antibodies in mice and humans. These antibodies are designed with altered binding properties of their Fc domain with neonatal Fc receptor (FcRn) or the Fab domain with their cognate target...
Gardado en:
| Publicado en: | AAPS J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6486833/ https://ncbi.nlm.nih.gov/pubmed/29541870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-017-0183-4 |
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