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A minimal physiologically based pharmacokinetic model to investigate FcRn-mediated monoclonal antibody salvage: Effects of K(on), K(off), endosome trafficking, and animal species
Manipulation of binding affinity between monoclonal antibodies (mAbs) and the neonatal Fc receptor (FcRn) has been leveraged to extend mAb half-life; however, the steps required for success remain ambiguous and experimental observations are inconsistent. Recent models have considered the time course...
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| Publicado no: | MAbs |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284604/ https://ncbi.nlm.nih.gov/pubmed/30130450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1506648 |
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