Aberrant oligodendroglial-vascular interactions disrupt the Blood Brain Barrier triggering CNS inflammation

Disruption of the BBB is critical to initiation and perpetuation of disease in Multiple Sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal rodent demyelinating injury. We find perivascular clustering of olig...

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Bibliografske podrobnosti
izdano v:Nat Neurosci
Main Authors: Niu, Jianqin, Tsai, Hui-Hsin, Hoi, Kimberly K., Huang, Nanxin, Yu, Guangdan, Kim, Kicheol, Baranzini, Sergio E., Xiao, Lan, Chan, Jonah R., Fancy, Stephen P.J.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486410/
https://ncbi.nlm.nih.gov/pubmed/30988524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0369-4
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