Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia

Oligodendrocytes express low-density lipoprotein receptor (LDLR) to endocytose cholesterol for the maintenance of adulthood myelination. However, the potential role of LDLR in chronic cerebral ischemia–related demyelination remains unclear. We used bilateral carotid artery stenosis (BCAS) to induce...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Xie, Yi, Zhang, Xiaohao, Xu, Pengfei, Zhao, Nana, Zhao, Ying, Li, Yunzi, Hong, Ye, Peng, Mengna, Yuan, Kang, Wan, Ting, Sun, Rui, Chen, Deyan, Xu, Lili, Chen, Jingjing, Guo, Hongquan, Shan, Wanying, Li, Juanji, Li, Rongrong, Xiong, Yunyun, Liu, Dezhi, Wang, Yuhui, Liu, George, Ye, Ruidong, Liu, Xinfeng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773390/
https://ncbi.nlm.nih.gov/pubmed/33141760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128114
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