USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells

The mesenchymal (MES) subtype of glioblastoma (GBM) stem cells (GSCs) represents a subpopulation of cancer cells that are notorious for their highly aggressive nature and resistance to conventional therapy. Aldehyde dehydrogenase 1A3 (ALDH1A3) has been recently suggested as a key determinant for the...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Chen, Zhengxin, Wang, Hong-Wei, Wang, Shuai, Fan, Ligang, Feng, Shuang, Cai, Xiaomin, Peng, Chenghao, Wu, Xiaoting, Lu, Jiacheng, Chen, Dan, Chen, Yuanyuan, Wu, Wenting, Lu, Daru, Liu, Ning, You, Yongping, Wang, Huibo
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486342/
https://ncbi.nlm.nih.gov/pubmed/30958800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126414
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