Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration

Aside from its catalytic function in protein synthesis, leucyl-tRNA synthetase (LRS) has a nontranslational function in regulating cell growth via the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) pathway by sensing amino acid availability. mTOR also regulates skeletal myogenesis, but the...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Son, Kook, You, Jae-Sung, Yoon, Mee-Sup, Dai, Chong, Kim, Jong Hyun, Khanna, Nidhi, Banerjee, Aditi, Martinis, Susan A., Han, Gyoonhee, Han, Jung Min, Kim, Sunghoon, Chen, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486340/
https://ncbi.nlm.nih.gov/pubmed/30985292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122560
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