Application of Threonine Aldolases for the Asymmetric Synthesis of α‐Quaternary α‐Amino Acids

We report the synthesis of diverse β‐hydroxy‐α,α‐dialkyl‐α‐amino acids with perfect stereoselectivity for the α‐quaternary center through the action of l‐ and d‐specific threonine aldolases. A wide variety of aliphatic and aromatic aldehydes were accepted by the enzymes and conversions up to >80 ...

Deskribapen osoa

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Xehetasun bibliografikoak
Argitaratua izan da:ChemCatChem
Egile Nagusiak: Blesl, Julia, Trobe, Melanie, Anderl, Felix, Breinbauer, Rolf, Strohmeier, Gernot A., Fesko, Kateryna
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Full Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485451/
https://ncbi.nlm.nih.gov/pubmed/31057675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cctc.201800611
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