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Application of Threonine Aldolases for the Asymmetric Synthesis of α‐Quaternary α‐Amino Acids

We report the synthesis of diverse β‐hydroxy‐α,α‐dialkyl‐α‐amino acids with perfect stereoselectivity for the α‐quaternary center through the action of l‐ and d‐specific threonine aldolases. A wide variety of aliphatic and aromatic aldehydes were accepted by the enzymes and conversions up to >80 ...

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Publicado en:ChemCatChem
Autores principales: Blesl, Julia, Trobe, Melanie, Anderl, Felix, Breinbauer, Rolf, Strohmeier, Gernot A., Fesko, Kateryna
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485451/
https://ncbi.nlm.nih.gov/pubmed/31057675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cctc.201800611
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