Application of Threonine Aldolases for the Asymmetric Synthesis of α‐Quaternary α‐Amino Acids

We report the synthesis of diverse β‐hydroxy‐α,α‐dialkyl‐α‐amino acids with perfect stereoselectivity for the α‐quaternary center through the action of l‐ and d‐specific threonine aldolases. A wide variety of aliphatic and aromatic aldehydes were accepted by the enzymes and conversions up to >80 ...

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Vydáno v:ChemCatChem
Hlavní autoři: Blesl, Julia, Trobe, Melanie, Anderl, Felix, Breinbauer, Rolf, Strohmeier, Gernot A., Fesko, Kateryna
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485451/
https://ncbi.nlm.nih.gov/pubmed/31057675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cctc.201800611
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